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Go or No Go: Pediatric Pre-sedation Assessment

Preparation and Consideration in Special Populations

Details in Audio; Topics Covered:

Asthma and Reactive Airway Disease

Autism, Developmental Delay, and Intellectual Disability

Cannabis Use

Cerebral Palsy

Congenital Heart Disease

Cystic Fibrosis

Diabetes Mellitus

Endocrinopathies

Mitochondrial Disease

Muscular Dystrophies

Obstructive Sleep Apnea

Premature Infant

Sickle Cell Disease

Syndromes

Upper Respiratory Tract Infection

 

STOP BANG Questionnaire — Adult (one point each)

Snoring — Do you Snore Loudly (loud enough to be heard through closed doors or your bed-partner elbows you for snoring at night)?

Tired — Do you often feel Tired, Fatigued, or Sleepy during the daytime (such as falling asleep during driving or talking to someone)?

Observed apnea — Has anyone Observed you Stop Breathing or Choking/Gasping during your sleep ?

Pressure — Do you have or are being treated for High Blood Pressure ?

BMI — Body Mass Index more than 35 kg/m2?

Age — Age older than 50?

Neck circumference — Is your shirt collar 16 inches / 40cm or larger?

Gender — Male?

OSA – Low Risk: Yes to 0 – 2 questions
OSA – Intermediate Risk: Yes to 3 – 4 questions
OSA – High Risk: Yes to 5 – 8 questions

 

Teen STOP BANG Questionnaire (one point each)

Snoring — Does your child snore?

Tired — Is your child tired or sleepy during the day?

Observed — Does your child stop breathing during sleep?

Pressure — BP ≥ 95th percentile for age and height?

BMI — Body Mass Index ≥ 95th percentile for age?

Academic — Does your child have trouble in school?

Neck — Circumference ≥ 95th percentile for age?

Gender — Male?

OSA – Low Risk: Yes to 0 – 2 questions
OSA – Intermediate Risk: Yes to 3 – 4 questions
OSA – High Risk: Yes to 5 – 8 questions

 

American College of Emergency Physicians — Clinical Policy on Procedural Sedation

 

American College of Emergency Physicians — Fasting Guidelines 

Green et al. Fasting and emergency department procedural sedation and analgesia: a consensus-based clinical practice advisory. Ann Emerg Med. 2007 Apr;49(4):454-61.

Bottom Line: 

Do not delay procedural sedation in adults or pediatrics in the ED based on fasting time. Preprocedural fasting for any duration has not demonstrated a reduction in the risk of emesis or aspiration when administering procedural sedation and analgesia.” (Level B Recommendation)

 

COLDS Score (for OR use)

C

Current signs/symptoms

None

Mild

Examples: Parent confirms URI AND/OR congestion, rhinorrhea, sore throat, sneezing, low fever, or dry cough

Moderate/severe

Examples: Purulence, wet cough, abnormal lung sounds, lethargy, ‘toxic’ appearance, or high fever

O

Onset

>4 weeks ago 2–4 weeks ago <2 Weeks ago

L

Lung disease

None

Mild

Examples: Hx of RSV, mild intermittent asthma, CLD if >1 year old, loud snoring, or passive smoker

Moderate/severe

Examples: Moderate persistent asthma, infant with CLD, OSA, or pulmonary HTN

D

Airway device

None or facemask Laryngeal mask airway or supraglottic Tracheal tube

S

Surgery

Other (including ear tubes)

Minor airway

Examples: T/A, NLD probe, flexible bronchoscopy, and dental extractions

Major airway

Examples: Cleft palate, rigid bronchoscopy, and maxillofacial

References

1. Splinter WM, Schreiner MS. Preoperative fasting in children. Anesthesia and analgesia. 1999;89(1):80-9.
2. Roberts RB, Shirley MA. Reducing the risk of acid aspiration during cesarean section. Anesthesia and analgesia. 1974;53(6):859-68.
3. Nordgren B. The rate of secretion and electrolyte content of normal gastric juice. Acta Physiol Scand Suppl. 1963;58(202):1-83.
4. Thomas M, Morrison C, Newton R, Schindler E. Consensus statement on clear fluids fasting for elective pediatric general anesthesia. Paediatr Anaesth. 2018;28(5):411-4.
5. Andersson H, Frykholm P. Gastric content assessed with gastric ultrasound in paediatric patients prescribed a light breakfast prior to general anaesthesia. A prospective observational study. Paediatr Anaesth. 2019.
6. Krauss B, Green SM. Sedation and analgesia for procedures in children. The New England journal of medicine. 2000;342(13):938-45.
7. Warner MA, Warner ME, Warner DO, Warner LO, Warner EJ. Perioperative pulmonary aspiration in infants and children. Anesthesiology. 1999;90(1):66-71.
8. Kelly CJ, Walker RWM. Perioperative pulmonary aspiration is infrequent and low risk in pediatric anesthetic practice. Paediatr Anaesth. 2015;25(1):36-43.
9. Habre W, Disma N, Virag K, Becke K, Hansen TG, Johr M, et al. Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe. Lancet Respir Med. 2017;5(5):412-25.
10. Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology. 1993;78(1):56-62.
11. Cravero JP, Beach ML, Blike GT, Gallagher SM, Hertzog JH. The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium. Anesthesia and analgesia. 2009;108(3):795-804.
12. Sanborn PA, Michna E, Zurakowski D, Burrows PE, Fontaine PJ, Connor L, et al. Adverse cardiovascular and respiratory events during sedation of pediatric patients for imaging examinations. Radiology. 2005;237(1):288-94.
13. Jones MJ, Mitchell RW, Hindocha N. Effect of increased intra-abdominal pressure during laparoscopy on the lower esophageal sphincter. Anesthesia and analgesia. 1989;68(1):63-5.
14. Practice guidelines for preoperative fasting and the use of pharmacologic agents to reduce the risk of pulmonary aspiration: application to healthy patients undergoing elective procedures: a report by the American Society of Anesthesiologist Task Force on Preoperative Fasting. Anesthesiology. 1999;90(3):896-905.
15. Bhatt M, Johnson DW, Taljaard M, Chan J, Barrowman N, Farion KJ, et al. Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children. JAMA Pediatr. 2018;172(7):678-85.
16. Green SM, Roback MG, Miner JR, Burton JH, Krauss B. Fasting and emergency department procedural sedation and analgesia: a consensus-based clinical practice advisory. Annals of emergency medicine. 2007;49(4):454-61.
17. Agrawal D, Manzi SF, Gupta R, Krauss B. Preprocedural fasting state and adverse events in children undergoing procedural sedation and analgesia in a pediatric emergency department. Ann Emerg Med. 2003;42(5):636-46.
18. Kaufman RA. Technical aspects of abdominal CT in infants and children. AJR Am J Roentgenol. 1989;153(3):549-54.
19. Kim SK. Small intestine transit time in the normal small bowel study. Am J Roentgenol Radium Ther Nucl Med. 1968;104(3):522-4.
20. Kharazmi SA, Kamat PP, Simoneaux SF, Simon HK. Violating traditional NPO guidelines with PO contrast before sedation for computed tomography. Pediatr Emerg Care. 2013;29(9):979-81.
21. Mahmoud M, McAuliffe J, Kim HY, Mishra P, Salisbury S, Schnell B, et al. Oral contrast for abdominal computed tomography in children: the effects on gastric fluid volume. Anesthesia and analgesia. 2010;111(5):1252-8.
22. Mahmoud M, McAuliffe J, Donnelly LF. Administration of enteric contrast material before abdominal CT in children: current practices and controversies. Pediatr Radiol. 2011;41(4):409-12.
23. Schmitz A, Schmidt AR. Can we use ultrasound examination of gastric content as a diagnostic test in clinical anaesthesia? Paediatr Anaesth. 2019;29(2):112-3.
24. Grunwell JR, Marupudi NK, Gupta RV, Travers CD, McCracken CE, Williamson JL, et al. Outcomes following implementation of a pediatric procedural sedation guide for referral to general anesthesia for magnetic resonance imaging studies. Paediatr Anaesth. 2016;26(6):628-36.
25. Doherty GM, Chisakuta A, Crean P, Shields MD. Anesthesia and the child with asthma. Pediatr Anesth. 2005;2005(15):446-54.
26. National Heart L, and Blood Institute. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. National Asthma Education and Prevention Program. 2007.
27. Von Ungern-Sternberg B, Habre W. Pediatric anesthesia – potential risks and their assessment: part I. Pediatr Anesth. 2007;17:206-15.
28. Rock P, Passannante A. Preoperative assessment: pulmonary. Anesthesiol Clin North America. 2004;22(77-91).
29. von Ungern-Sternberg BS, Boda K, Chambers NA, Rebman C, Johnson C, Sly PD, et al. Risk assessment for respiratory complications in paediatric anaesthesia: a prospective cohort study. Lancet. 2010;376:773-83.
30. Tchaconas A, Adesman A. Autism spectrum disoders: a pediatric overview and update. Curr Opin Pediatr. 2013;25(1):130-44.
31. Courtman SP, Mumby D. Children with learning disabilities. Pediatr Anesth. 2008;18:198-207.
32. Harris P. The nature and extent of aggressive behavior amongst people with learning difficulties (mental handicap) in a single health district. J Intellect Disabil Res. 1993;39:221-42.
33. Emerson E, Bromley J. The form and function of challenging behaviours. J Intellect Disabil Res. 1995;3:388-98.
34. Elliott AB, Holley AL, Ross AC, Soleta AO, Koh JL. A prospective study comparing perioperative anxiety and posthospital behavior in children with autism spectrum disorder vs typically developing children undergoing outpatient surgery. Paediatr Anaesth. 2018;28(2):142-8.
35. Elwood T, Hansen LD, Seely JM. Oropharyngeal Airway Diameter During Sedation in Children With and Without Developmental Delay J Clin Anesth. 2001;13:482-5.
36. Lewis I, Burke C, Voepel-Lewis T, Tait AR. Children who refuse anesthesia or sedation: a survey of anesthesiologists. Pediatr Anesth. 2007;17:1134-42.
37. Taghizadeh N, Heard G, Davidson A, Williams K, Story D. The experiences of children with autism spectrum disorder, their caregivers and health care providers during day procedure: A mixed methods study. Paediatr Anaesth. 2019;29(9):927-37.
38. Goodman G, Perkin RM, Anas NG, Sperling DR, Hicks DA, Rowen M. Pulmonary hypertension in infants with bronchopulmonary dysplasia. The Journal of pediatrics. 1988;112(1):67-72.
39. Flannery KM, D’Souza G, Agarwal R. Perioperative Management of the Pediatric Patient on Medicinal Marijuana: What Anesthesiologists Should Know. Anesthesia and analgesia. 2019;129(5):1339-43.
40. Kunos G, Jarai Z, Batkai S, Goparaju SK, Ishac EJ, Liu J, et al. Endocannabinoids as cardiovascular modulators. Chem Phys Lipids. 2000;108(1-2):159-68.
41. Grotenhermen F. Pharmacokinetics and pharmacodynamics of cannabinoids. Clin Pharmacokinet. 2003;42(4):327-60.
42. Pertwee RG. Neuropharmacology and therapeutic potential of cannabinoids. Addict Biol. 2000;5(1):37-46.
43. Huson HB, Granados TM, Rasko Y. Surgical considerations of marijuana use in elective procedures. Heliyon. 2018;4(9):e00779.
44. Ammerman S, Ryan S, Adelman WP, Committee on Substance Abuse tCoA, Levy S, Ammerman SD, et al. The impact of marijuana policies on youth: clinical, research, and legal update. Pediatrics. 2015;135(3):e769-85.
45. Stanley F, Blair E, Alberman E. Cerebral palsies: Epidemiology and Causal Pathways: Mac Keith Press; 2000.
46. Nelson KB. Can we prevent cerebral palsy? N Engl J Med. 2003;349(18):1765-9.
47. Strijbis EM, Oudman I, van Essen P, MacLennan AH. Cerebral palsy and the application of the international criteria for acute intrapartum hypoxia. Obstetrics and gynecology. 2006;107(6):1357-65.
48. Novak I, Hines M, Goldsmith S, Barclay R. Clinical prognostic messages from a systematic review on cerebral palsy. Pediatrics. 2012;130(5):e1285-312.
49. Wongprasartsuk P, Stevens J. Cerebral palsy and anaesthesia. Paediatric anaesthesia. 2002;12(4):296-303.
50. Collier J. The management of spasticity. Drug and Therapeutics Bulletin. 2000;38(6):44-6.
51. Valkenburg AJ, van der Kreeft SM, de Leeuw TG, Stolker RJ, Tibboel D, van Dijk M. Pain management in intellectually disabled children: a survey of perceptions and current practices among Dutch anesthesiologists. Paediatric anaesthesia. 2012;22(7):682-9.
52. Malviya S, Voepel-Lewis T, Merkel S, Tait AR. Difficult pain assessment and lack of clinician knowledge are ongoing barriers to effective pain management in children with cognitive impairment. Acute Pain. 2005;7(1):27-32.
53. Geary T, Negus A, Anderson BJ, Zernikow B. Perioperative management of the child on long-term opioids. Paediatric anaesthesia. 2012;22(3):189-202.
54. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A. Prevalence of congenital heart defects in metropolitan Atlanta, 1998-2005. The Journal of pediatrics. 2008;153(6):807-13.
55. White MC. Approach to managing children with heart disease for noncardiac surgery. Pediatric Anesthesia. 2011;21(5):522-9.
56. Rosenthal DN, Hammer GB. Cardiomyopathy and heart failure in children: anesthetic implications. Paediatric anaesthesia. 2011;21(5):577-84.
57. Diaz LK, Jones L. Sedating the child with congenital heart disease. Anesthesiology clinics. 2009;27(2):301-19.
58. Rosenthal D, Chrisant MR, Edens E, Mahony L, Canter C, Colan S, et al. International Society for Heart and Lung Transplantation: Practice guidelines for management of heart failure in children. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2004;23(12):1313-33.
59. Ross RD. The Ross classification for heart failure in children after 25 years: a review and an age-stratified revision. Pediatric cardiology. 2012;33(8):1295-300.
60. Jessup M, Abraham WT, Casey DE, Feldman AM, Francis GS, Ganiats TG, et al. 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in AdultsA Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation. Journal of the American College of Cardiology. 2009;53(15):1343-82.
61. Ross RD, Bollinger RO, Pinsky WW. Grading the severity of congestive heart failure in infants. Pediatric cardiology. 1992;13(2):72-5.
62. Navaratnam M, Dubin A. Pediatric pacemakers and ICDs: how to optimize perioperative care. Paediatric anaesthesia. 2011;21(5):512-21.
63. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Circulation. 2007;116(15):1736-54.
64. Ratjen F, Doring G. Cystic fibrosis. Lancet. 2003;361(9358):681-9.
65. Huffmyer JL, Littlewood KE, Nemergut EC. Perioperative management of the adult with cystic fibrosis. Anesthesia and analgesia. 2009;109(6):1949-61.
66. Fitzgerald M, Ryan D. Cystic fibrosis and anaesthesia. Continuing Education in Anaesthesia, Critical Care & Pain. 2011;11(6):204-9.
67. Gibson RL, Burns JL, Ramsey BW. Pathophysiology and management of pulmonary infections in cystic fibrosis. American journal of respiratory and critical care medicine. 2003;168(8):918-51.
68. Kearns GL, Mallory GB, Jr., Crom WR, Evans WE. Enhanced hepatic drug clearance in patients with cystic fibrosis. The Journal of pediatrics. 1990;117(6):972-9.
69. Dray X, Bienvenu T, Desmazes-Dufeu N, Dusser D, Marteau P, Hubert D. Distal intestinal obstruction syndrome in adults with cystic fibrosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2004;2(6):498-503.
70. Chhajed PN, Aboyoun C, Chhajed TP, Malouf MA, Harrison GA, Tamm M, et al. Sedative drug requirements during bronchoscopy are higher in cystic fibrosis after lung transplantation. Transplantation. 2005;80(8):1081-5.
71. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes care. 2011/01/14 ed2011. p. S62-9.
72. Chadwick V, Wilkinson KA. Diabetes mellitus and the pediatric anesthetist. Paediatric anaesthesia. 2004;14(9):716-23.
73. Gavin LA. Perioperative management of the diabetic patient. Endocrinology and metabolism clinics of North America. 1992;21(2):457-75.
74. Wu CC, Lin CS, Mok MS. Bispectral index monitoring during hypoglycemic coma. J Clin Anesth. 2002;14(4):305-6.
75. Partridge H, Perkins B, Mathieu S, Nicholls A, Adeniji K. Clinical recommendations in the management of the patient with type 1 diabetes on insulin pump therapy in the perioperative period: a primer for the anaesthetist. Br J Anaesth. 2016;116(1):18-26.
76. Lamberts SW, Bruining HA, de Jong FH. Corticosteroid therapy in severe illness. The New England journal of medicine. 1997;337(18):1285-92.
77. Glowniak JV, Loriaux DL. A double-blind study of perioperative steroid requirements in secondary adrenal insufficiency. Surgery. 1997;121(2):123-9.
78. Jacobi J. Corticosteroid replacement in critically ill patients. Critical care clinics. 2006;22(2):245-53, vi.
79. Tsubokawa T, Yamamoto K, Kobayashi T. Propofol clearance and distribution volume increase in patients with hyperthyroidism. Anesthesia and analgesia. 1998;87(1):195-9.
80. Driessen J, Willems S, Dercksen S, Giele J, van der Staak F, Smeitink J. Anesthesia-related morbidity and mortality after surgery for muscle biopsy in children with mitochondrial defects. Paediatric anaesthesia. 2007;17(1):16-21.
81. Steriade C, Andrade DM, Faghfoury H, Tarnopolsky MA, Tai P. Mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) may respond to adjunctive ketogenic diet. Pediatr Neurol. 2014;50(5):498-502.
82. McNeely JK. Perioperative management of a paediatric patient on the ketogenic diet. Paediatr Anaesth. 2000;10(1):103-6.
83. Lerman J. Perioperative management of the paediatric patient with coexisting neuromuscular disease. British journal of anaesthesia. 2011;107 Suppl 1:i79-89.
84. McFarland R, Taylor RW, Turnbull DM. A neurological perspective on mitochondrial disease. Lancet neurology. 2010;9(8):829-40.
85. Kam PC, Cardone D. Propofol infusion syndrome. Anaesthesia. 2007;62(7):690-701.
86. Scaravilli V, Zanella A, Ciceri V, Bosatra M, Flandoli C, La Bruna A, et al. Safety of anesthesia for children with mucopolysaccharidoses: A retrospective analysis of 54 patients. Paediatr Anaesth. 2018;28(5):436-42.
87. Wang LYJ, Ross AK, Li JS, Dearmey SM, Mackey JF, Worden M, et al. Cardiac arrhythmias following anesthesia induction in infantile-onset Pompe disease: a case series. Paediatr Anaesth. 2007;17(8):738-48.
88. Anderson J. Allergic and Allergic-Like Reactions to Drugs and Other Therapeutic Agents. In: Lieberman P, Anderson J, editors. Allergic Diseases. Current Clinical Practice: Humana Press; 2007. p. 295-318.
89. Khan DA. Treating patients with multiple drug allergies. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2013;110(1):2-6.
90. Caubet JC, Eigenmann PA. Diagnostic issues in pediatric drug allergy. Current opinion in allergy and clinical immunology. 2012;12(4):341-7.
91. Gonzalez-Gregori R, Dolores Hernandez Fernandez De Rojas M, Lopez-Salgueiro R, Diaz-Palacios M, Garcia AN. Allergy alerts in electronic health records for hospitalized patients. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2012;109(2):137-40.
92. Asero R. Multiple drug allergy syndrome: A distinct clinical entity. Curr Allergy Asthma Rep. 2001;1(1):18-22.
93. Patriarca G, Schiavino D, Nucera E, Colamonico P, Montesarchio G, Saraceni C. Multiple drug intolerance: allergological and psychological findings. Journal of investigational allergology & clinical immunology : official organ of the International Association of Asthmology (INTERASMA) and Sociedad Latinoamericana de Alergia e Inmunologia. 1991;1(2):138-44.
94. Schiavino D, Nucera E, Roncallo C, Pollastrini E, De Pasquale T, Lombardo C, et al. Multiple-drug intolerance syndrome: clinical findings and usefulness of challenge tests. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2007;99(2):136-42.
95. De Pasquale T, Nucera E, Boccascino R, Romeo P, Biagini G, Buonomo A, et al. Allergy and psychologic evaluations of patients with multiple drug intolerance syndrome. Internal and emergency medicine. 2012;7(1):41-7.
96. Emery AE. The muscular dystrophies. Lancet. 2002;359(9307):687-95.
97. Hayes J, Veyckemans F, Bissonnette B. Duchenne muscular dystrophy: an old anesthesia problem revisited. Paediatric anaesthesia. 2008;18(2):100-6.
98. American Academy of Pediatrics Section on Cardiology and Cardiac Surgery.. Cardiovascular health supervision for individuals affected by Duchenne or Becker muscular dystrophy. Pediatrics. 2005;116:1569-73.
99. Groh WJ. Arrhythmias in the muscular dystrophies. Heart rhythm : the official journal of the Heart Rhythm Society. 2012;9(11):1890-5.
100. Romfh A, McNally EM. Cardiac assessment in duchenne and becker muscular dystrophies. Current heart failure reports. 2010;7(4):212-8.
101. Morgan GE, Mikhail MS, Murray MJ. Anesthesia for Patients with Neuromuscular Disease. Clinical Anesthesiology, 4th Edition: McGraw-Hill Medical; 2005.
102. Driessen J, Snoeck M. Duchenne muscular dystrophy: Which is the best anesthetic agent? Paediatric anaesthesia. 2008;18(10):1007-8.
103. Berry FA. Succinylcholine: a premature death knell? Pediatric Anesthesia. 1994;4(4):205-.
104. Veyckemans F. Can inhalation agents be used in the presence of a child with myopathy? Current opinion in anaesthesiology. 2010;23(3):348-55.
105. Raman V, Yacob D, Tobias JD. Dexmedetomidine-ketamine sedation during upper gastrointestinal endoscopy and biopsy in a patient with Duchenne muscular dystrophy and egg allergy. International journal of critical illness and injury science. 2012;2(1):40-3.
106. Ross AK. Muscular dystrophy versus mitochondrial myopathy: the dilemma of the undiagnosed hypotonic child. Paediatric anaesthesia. 2007;17(1):1-6.
107. Phan H, Nahata MC. Clinical uses of dexmedetomidine in pediatric patients. Paediatric drugs. 2008;10(1):49-69.
108. Lerman J. Perioperative management of the paediatric patient with coexisting neuromuscular disease. British Journal of Anaesthesia. 2011;107(suppl 1):i79-i89.
109. Zucconi M, Weber G, Castronovo V, Ferini-Strambi L, Russo F, Chiumello G, et al. Sleep and upper airway obstruction in children with achondroplasia. The Journal of pediatrics. 1996;129(5):743-9.
110. Nelson FW, Hecht JT, Horton WA, Butler IJ, Goldie WD, Miner M. Neurological basis of respiratory complications in achondroplasia. Annals of neurology. 1988;24(1):89-93.
111. Stynowick G, Tobias J. Perioperative care of the patient with osteogenesis imperfecta. Orthopedics. 2007;30(12):1043-9.
112. Widmann R, Bitan F, Laplaza F, Burke S, DiMaio M, Schneider R. Spinal deformity, pulmonary compromise, and quality of life in osteogenesis imperfecta. Spine. 1999;24(16):1673-8.
113. Fernbach SK, Brouillette RT, Riggs TW, Hunt CE. Radiologic evaluation of adenoids and tonsils in children with obstructive sleep apnea: plain films and fluoroscopy. Pediatr Radiol. 1983;13(5):258-65.
114. Schwengel DA, Sterni LM, Tunkel DE, Heitmiller ES. Perioperative management of children with obstructive sleep apnea. Anesth Analg. 2009;109(1):60-75.
115. Gross JB, Bachenberg KL, Benumof JL, Caplan RA, Connis RT, Cote CJ, et al. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: a report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Anesthesiology. 2006;104(5):1081-93; quiz 117-8.
116. Tait AR, Bickham R, O’Brien LM, Quinlan M, Voepel-Lewis T. The STBUR questionnaire for identifying children at risk for sleep-disordered breathing and postoperative opioid-related adverse events. Paediatr Anaesth. 2016;26(7):759-66.
117. Galvez JA, Yaport M, Maeder-Chieffo S, Simpao AF, Tan JM, Wasey JO, et al. STBUR: Sleep trouble breathing and unrefreshed questionnaire: Evaluation of screening tool for postanesthesia care and disposition. Paediatr Anaesth. 2019;29(8):821-8.
118. Chung F, Yegneswaran B, Liao P, Chung SA, Vairavanathan S, Islam S, et al. STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008;108(5):812-21.
119. Chung F, Subramanyam R, Liao P, Sasaki E, Shapiro C, Sun Y. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth. 2012;108(5):768-75.
120. Christensson E, Franklin KA, Sahlin C, Palm A, Ulfberg J, Eriksson LI, et al. Can STOP-Bang and Pulse Oximetry Detect and Exclude Obstructive Sleep Apnea? Anesthesia and analgesia. 2018;127(3):736-43.
121. Cote GA, Hovis CE, Hovis RM, Waldbaum L, Early DS, Edmundowicz SA, et al. A screening instrument for sleep apnea predicts airway maneuvers in patients undergoing advanced endoscopic procedures. Clin Gastroenterol Hepatol. 2010;8(8):660-5.e1.
122. Connolly LA. Anesthetic management of obstructive sleep apnea patients. Journal of Clinical Anesthesia. 1991;3(6):461-9.
123. Shorten GD, Opie NJ, Graziotti P, Morris I, Khangure M. Assessment of upper airway anatomy in awake, sedated and anaesthetised patients using magnetic resonance imaging. Anaesthesia & Intensive Care. 1994;22(2):165-9.
124. Eastwood PR, Platt PR, Shepherd K, Maddison K, Hillman DR. Collapsibility of the upper airway at different concentrations of propofol anesthesia. Anesthesiology. 2005;103(3):470-7.
125. Dhonneur G, Combes X, Leroux B, Duvaldestin P. Postoperative obstructive apnea. Anesth Analg. 1999;89(3):762-7.
126. Brouillette RT, Thach BT. A neuromuscular mechanism maintaining extrathoracic airway patency. Journal of Applied Physiology: Respiratory, Environmental & Exercise Physiology. 1979;46(4):772-9.
127. den Herder C, Schmeck J, Appelboom DJK, de Vries N. Risks of general anaesthesia in people with obstructive sleep apnoea. BMJ. 2004;329(7472):955-9.
128. Mahmoud M, Gunter J, Donnelly LF, Wang Y, Nick TG, Sadhasivam S. A comparison of dexmedetomidine with propofol for magnetic resonance imaging sleep studies in children. Anesth Analg. 2009;109(3):745-53.
129. Mahmoud M, Radhakrishman R, Gunter J, Sadhasivam S, Schapiro A, McAuliffe J, et al. Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children. Paediatric Anaesthesia. 2010;20(6):506-15.
130. Drummond GB. Comparison of sedation with midazolam and ketamine: effects on airway muscle activity. British Journal of Anaesthesia. 1996;76(5):663-7.
131. Char D, Drover DR, Motonaga KS, Gupta S, Miyake CY, Dubin AM, et al. The effects of ketamine on dexmedetomidine‐induced electrophysiologic changes in children. Pediatric Anesthesia. 2013;23(10):898-905.
132. Kandil A, Subramanyam R, Hossain MM, Ishman S, Shott S, Tewari A, et al. Comparison of the combination of dexmedetomidine and ketamine to propofol or propofol/sevoflurane for drug‐induced sleep endoscopy in children. Pediatric Anesthesia. 2016;26(7):742-51.
133. Koruk S, Mizrak A, Gul R, Kilic E, Yendi F, Oner U. Dexmedetomidine–ketamine and midazolam–ketamine combinations for sedation in pediatric patients undergoing extracorporeal shock wave lithotripsy: a randomized prospective study. Journal of anesthesia. 2010;24(6):858-63.
134. McVey JD, Tobias JD. Dexmedetomidine and ketamine for sedation during spinal anesthesia in children. Journal of clinical anesthesia. 2010;22(7):538-45.
135. Zor F, Ozturk S, Bilgin F, Isik S, Cosar A. Pain relief during dressing changes of major adult burns: ideal analgesic combination with ketamine. Burns. 2010;36(4):501-5.
136. Shank ES, Sheridan RL, Ryan CM, Keaney TJ, Martyn JJ. Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: a preliminary study. Journal of Burn Care & Research. 2013;34(3):311-7.
137. Mahmoud M, Radhakrishman R, Gunter J, Sadhasivam S, Schapiro A, McAULIFFE J, et al. Effect of increasing depth of dexmedetomidine anesthesia on upper airway morphology in children. Pediatric Anesthesia. 2010;20(6):506-15.
138. Mahmoud M, Jung D, Salisbury S, McAuliffe J, Gunter J, Patio M, et al. Effect of increasing depth of dexmedetomidine and propofol anesthesia on upper airway morphology in children and adolescents with obstructive sleep apnea. Journal of clinical anesthesia. 2013;25(7):529-41.
139. Mahmoud M, Ishman SL, McConnell K, Fleck R, Shott S, Mylavarapu G, et al. Upper airway reflexes are preserved during dexmedetomidine sedation in children with Down syndrome and obstructive sleep apnea. Journal of Clinical Sleep Medicine. 2017;13(05):721-7.
140. Cote CJ, Posner KL, Domino KB. Death or neurologic injury after tonsillectomy in children with a focus on obstructive sleep apnea: houston, we have a problem! Anesthesia and analgesia. 2014;118(6):1276-83.
141. Subramanyam R, Varughese A, Willging JP, Sadhasivam S. Future of pediatric tonsillectomy and perioperative outcomes. Int J Pediatr Otorhinolaryngol. 2013;77(2):194-9.
142. American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep a. Practice guidelines for the perioperative management of patients with obstructive sleep apnea: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Management of patients with obstructive sleep apnea. Anesthesiology. 2014;120(2):268-86.
143. Hamilton BE, Ventura SJ. Birth rates for U.S. teenagers reach historic lows for all age and ethnic groups. National Center for Health Statistics. 2012;NCHS data brief, no 89.
144. Acquavella AP, Braverman P. Adolescent gynecology in the office setting. Pediatric clinics of North America. 1999;46(3):489-503.
145. Givens TG, Jackson CL, Kulick RM. Recognition and management of pregnant adolescents in the pediatric emergency department. Pediatric emergency care. 1994;10(5):253-5.
146. Walton NKD, Melachuri VK. Anaesthesia for non-obstetric surgery during pregnancy. Continuing Education in Anaesthesia, Critical Care & Pain. 2006;6(2):83-5.
147. Prevention CfDCa. Pregnancy and Medicines. US Department of Health and Human Services, Office on Women’s Health. 2010.
148. Gynecologists ACoOa. ACOG educational bulletin. Teratology. Number 236, April 1997 (replaces no. 233, February 1997). American College of Obstetricians and Gynecologists. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 1997;57(3):319-26.
149. Addis A, Sharabi S, Bonati M. Risk classification systems for drug use during pregnancy: are they a reliable source of information? Drug safety : an international journal of medical toxicology and drug experience. 2000;23(3):245-53.
150. Rathmell JP, Viscomi CM, Ashburn MA. Management of nonobstetric pain during pregnancy and lactation. Anesthesia and analgesia. 1997;85(5):1074-87.
151. Welborn LG, Rice LJ, Hannallah RS, Broadman LM, Ruttimann UE, Fink R. Postoperative apnea in former preterm infants: prospective comparison of spinal and general anesthesia. Anesthesiology. 1990;72(5):838-42.
152. Miller MJ, Martin RJ. Apnea of prematurity. Clinics in perinatology. 1992;19(4):789-808.
153. Havidich JE, Beach M, Dierdorf SF, Onega T, Suresh G, Cravero JP. Preterm Versus Term Children: Analysis of Sedation/Anesthesia Adverse Events and Longitudinal Risk. Pediatrics. 2016;137(3):e20150463.
154. Webster AC, McKishnie JD, Watson JT, Reid WD. Lumbar epidural anaesthesia for inguinal hernia repair in low birth weight infants. Canadian journal of anaesthesia = Journal canadien d’anesthesie. 1993;40(7):670-5.
155. Kurth CD, Spitzer AR, Broennle AM, Downes JJ. Postoperative apnea in preterm infants. Anesthesiology. 1987;66(4):483-8.
156. Poets CF, Stebbens VA, Richard D, Southall DP. Prolonged episodes of hypoxemia in preterm infants undetectable by cardiorespiratory monitors. Pediatrics. 1995;95(6):860-3.
157. Services USDoHaH. Mental Health: A Report of the Surgeon General. Rockville, MD: U.S. Department of Health and Human Services; 2000.
158. Merikangas KR, Nakamura EF, Kessler RC. Epidemiology of mental disorders in children and adolescents. Dialogues in clinical neuroscience. 2009;11(1):7-20.
159. Belfer ML. Child and adolescent mental disorders: the magnitude of the problem across the globe. Journal of child psychology and psychiatry, and allied disciplines. 2008;49(3):226-36.
160. Palla B, Litt IF. Medical Complications of Eating Disorders in Adolescents. Pediatrics. 1988;81(5):613-23.
161. Takimoto Y, Yoshiuchi K, Kumano H, Yamanaka G, Sasaki T, Suematsu H, et al. QT interval and QT dispersion in eating disorders. Psychotherapy and psychosomatics. 2004;73(5):324-8.
162. Khan MU, Patel AG, Wilbur SL, Khan IA. Electrocardiographic changes in combined electrolyte depletion. International journal of cardiology. 2007;116(2):276-8.
163. Froehlich Te LBPEJNBWJKSKKRS. PRevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of us children. Archives of Pediatrics & Adolescent Medicine. 2007;161(9):857-64.
164. Steiner H, Remsing L. Practice parameter for the assessment and treatment of children and adolescents with oppositional defiant disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2007;46(1):126-41.
165. Roberts RE, Roberts CR, Xing Y. Rates of DSM-IV psychiatric disorders among adolescents in a large metropolitan area. Journal of psychiatric research. 2007;41(11):959-67.
166. Forsyth IAN, Bergesio R, Chambers NA. Attention-deficit hyperactivity disorder and anesthesia. Pediatric Anesthesia. 2006;16(4):371-3.
167. Hernandez M, Birnbach DJ, Van Zundert AA. Anesthetic management of the illicit-substance-using patient. Current opinion in anaesthesiology. 2005;18(3):315-24.
168. Steadman JL, Birnbach DJ. Patients on party drugs undergoing anesthesia. Current opinion in anaesthesiology. 2003;16(2):147-52.
169. Kayaalp L, Bozkurt P, Odabasi G, Dogangun B, Cavusoglu P, Bolat N, et al. Psychological effects of repeated general anesthesia in children. Paediatric anaesthesia. 2006;16(8):822-7.
170. Watson AT, Visram A. Children’s preoperative anxiety and postoperative behaviour. Paediatric anaesthesia. 2003;13(3):188-204.
171. Fortier MA, Del Rosario AM, Rosenbaum A, Kain ZN. Beyond pain: predictors of postoperative maladaptive behavior change in children. Paediatric anaesthesia. 2010;20(5):445-53.
172. Christiansen E, Chambers N. Induction of anesthesia in a combative child; management and issues. Pediatr Anesth. 2005;15:421-5.
173. Marchant WA, Walker I. Anaesthetic management of the child with sickle cell disease. Paediatric anaesthesia. 2003;13(6):473-89.
174. Eaton WA, Hofrichter J. Hemoglobin S gelation and sickle cell disease. Blood. 1987;70(5):1245-66.
175. Swerdlow PS. Red Cell Exchange in Sickle Cell Disease. ASH Education Program Book. 2006;2006(1):48-53.
176. Wayne AS, Kevy SV, Nathan DG. Transfusion management of sickle cell disease. Blood. 1993;81(5):1109-23.
177. Crawford MW, Galton S, Naser B. Postoperative morphine consumption in children with sickle-cell disease. Paediatric anaesthesia. 2006;16(2):152-7.
178. Ballas SK. Current Issues in Sickle Cell Pain and Its Management. ASH Education Program Book. 2007;2007(1):97-105.
179. Ogundipe O, Walker M, Pearson TC, Slater NGP, Adepegba T, Westerdale N. Sickle cell disease and nitrous oxide-induced neuropathy. Clinical & Laboratory Haematology. 1999;21(6):409-12.
180. Carbajal R, Hubert P, Treluyer JM, Jouvet P, Olivier-Martin M. Nitrous oxide and morphine in children with sickle cell crisis. Lancet. 1996;347(9015):1621.
181. McGarry P, Duncan C. Anesthetic risks in sickle cell trait. Pediatrics. 1973;51(3):507-12.
182. Jones KL. Smith’s Recognizable patterns of Human Malformation. Philadelphia, PA: Elsevier; 2006.
183. Frei FJ, Ummenhofer W. Difficult intubation in paediatrics. Paediatric anaesthesia. 1996;6(4):251-63.
184. Nargozian C. The airway in patients with craniofacial abnormalities. Paediatric anaesthesia. 2004;14(1):53-9.
185. Mitchell V, Howard R, Facer E. Down’s syndrome and anaesthesia. Paediatric anaesthesia. 1995;5(6):379-84.
186. Barnett S, Moloney C, Bingham R. Perioperative complications in children with Apert syndrome: a review of 509 anesthetics. Paediatric anaesthesia. 2011;21(1):72-7.
187. Borland LM, Colligan J, Brandom BW. Frequency of anesthesia-related complications in children with Down syndrome under general anesthesia for noncardiac procedures. Paediatric anaesthesia. 2004;14(9):733-8.
188. Kraemer FW, Stricker PA, Gurnaney HG, McClung H, Meador MR, Sussman E, et al. Bradycardia during induction of anesthesia with sevoflurane in children with Down syndrome. Anesthesia and analgesia. 2010;111(5):1259-63.
189. Kleinman ME, Chameides L, Schexnayder SM, Samson RA, Hazinski MF, Atkins DL, et al. Pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Pediatrics. 2010;126(5):e1361-99.
190. Surgeons ACo. ATLS: Advanced Trauma Life Support Program for Doctors (9th ed.). Trauma Co, editor. Chicago, IL: American College of Surgeons; 2012.
191. Benyounes N, Fohlen M, Devys JM, Delalande O, Moures JM, Cohen A. Cardiac rhabdomyomas in tuberous sclerosis patients: a case report and review of the literature. Archives of cardiovascular diseases. 2012;105(8-9):442-5.
192. Lee JJ, Imrie M, Taylor V. Anaesthesia and tuberous sclerosis. British journal of anaesthesia. 1994;73(3):421-5.
193. Septer S, Thompson ES, Willemsen-Dunlap A. Anesthesia concerns for children with tuberous sclerosis. AANA journal. 2006;74(3):219-25.
194. Elwood T, Bailey K. The pediatric patient and upper respiratory infections. Best practice & research Clinical anaesthesiology. 2005;19(1):35-46.
195. Schreiner MS, O’Hara I, Markakis DA, Politis GD. Do children who experience laryngospasm have an increased risk of upper respiratory tract infection? Anesthesiology. 1996;85(3):475-80.
196. Parnis SJ, Barker DS, Van Der Walt JH. Clinical predictors of anaesthetic complications in children with respiratory tract infections. Paediatric anaesthesia. 2001;11(1):29-40.
197. Lee LK, Bernardo MKL, Grogan TR, Elashoff DA, Ren WHP. Perioperative respiratory adverse event risk assessment in children with upper respiratory tract infection: Validation of the COLDS score. Paediatr Anaesth. 2018;28(11):1007-14.
198. Tait AR, Malviya S. Anesthesia for the child with an upper respiratory tract infection: still a dilemma? Anesthesia and analgesia. 2005;100(1):59-65.
199. Girmay Fitiwi Lema YWB, Amare Hailekiros Gebrezgi ,, Getu AA. Evidence-based perioperative management of a child with upper respiratory tract infections (URTIs) undergoing elective surgery; A systematic review. International Journal of Surgery Open. 2018;12: 17-24.
200. Cote CJ. The upper respiratory tract infection (URI) dilemma: fear of a complication or litigation? Anesthesiology. 2001;95(2):283-5.
201. Burke GM, Burke AM, Sherma AK, Hurley MC, Batjer HH, Bendok BR. Moyamoya disease: a summary. Neurosurgical focus. 2009;26(4):E11.
202. Deng X, Ge P, Wang S, Zhang D, Zhang Y, Wang R, et al. Treatment of Moyamoya Disease. Neurosurgery. 2018;65(CN_suppl_1):62-5.
203. Parray T, Martin TW, Siddiqui S. Moyamoya disease: a review of the disease and anesthetic management. Journal of neurosurgical anesthesiology. 2011;23(2):100-9.